[Solved]: Tobramycin is an effective bactericidal in the plasma…

Tobramycin is an effective bactericidal in the plasma concentration range 4–8 mcg/mL to most Gram-negative organisms. Simon et al. (Antimicrob Agents Chemother 1973; 3: 445) reported the elimination half life and the volume of distribution of tobramycin to be 1.60 h and 0.241 L/ kg, respectively. If 3 mL (60 mg/1.5 mL) of tobramycin is administered as an intravenous bolus to a normal healthy subject (66.666 kg weight), what will be the duration of action for the administered dose?