[Solved]: Your client has been on the same dose of warfarin for…

Your client has been on the same dose of warfarin for many years, without any issues. Recently they have developed acute renal failure, which will impact on their drug regimen. Which of the following reflect this change? Drug elimination will be altered. Protein binding will be altered as the kidneys are responsible for albumin production. Drug metabolism will be altered. Maintaining the dose of warfarin will give a risk of bleeding. The drug pharmacokinetics will be altered. The dosage of warfarin will likely need to be reduced. Drug distribution will be reduced. Protein binding will be altered as the kidneys will leak albumin. More drug will be distributed to the tissues.