[Solved]: Antidepressants SEROTONIN/NOREPINEPHRINE REUPTAKE…

Antidepressants SEROTONIN/NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) Prototype: Venlafaxine (Effexor) Other SNRIs Duloxetine (Cymbalta) (indicated for physical pain and diabetic neuropathy; can cause liver toxicity) 6 Desvenlafaxine (Pristiq) Mechanism of Action Blocks norepinephrine (NE) and 5-HT uptake; weak blockade of dopamine uptake Uses Major depression, generalized anxiety disorder Social anxiety disorder (social phobia) Adverse Effects Nausea, headache, anorexia, nervousness, sweating, somnolence, and insomnia Weight loss, diastolic hypertension Sexual dysfunction, hyponatremia Increased risk of suicide Intense withdrawal syndrome with abrupt discontinuation (anxiety, agitation, tremors, headache, vertigo, nausea, tachycardia, timnitus) Neonatal withdrawal syndrome Serotonin syndrome